3-isocyanatothiophene-2-carboxylic acid methyl ester
Methyl 3-isocyanatothiophene-2-carboxylate
CAS: 25712-16-7
Molecular Formula: C7H5NO3S
3-isocyanatothiophene-2-carboxylic acid methyl ester - Names and Identifiers
3-isocyanatothiophene-2-carboxylic acid methyl ester - Physico-chemical Properties
| Molecular Formula | C7H5NO3S |
| Molar Mass | 183.18 |
| Density | 1.34±0.1 g/cm3(Predicted) |
| Melting Point | 54-56 °C |
| Boling Point | 105-110 °C(Press: 3 Torr) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD09971934 |
3-isocyanatothiophene-2-carboxylic acid methyl ester - Introduction
Methyl 3-isocyanothiophene-2-carboxylate is an organic compound. Its molecular formula is C8H5NO3S and its molecular weight is 195.19g/mol. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: Colorless to light yellow solid
-Melting point: 65-69°C
-Boiling point: 383°C
-Stability: stable at room temperature, but easy to get damp
-Solubility: Soluble in common organic solvents such as ethanol, acetone and dimethylformamide
Use:
-Methyl 3-isocyanothiophene-2-carboxylate is useful as an intermediate or reagent in organic synthesis.
Preparation Method:
The preparation of methyl 3-isocyanothiophene-2-carboxylate is generally carried out by the following steps:
1. First, thiophene-2-carboxylic acid ester reacts with imidazole under the action of carbonate to form thiophene-2-carboxylic acid imidazole salt.
2. Then, thiophene -2-carboxylic acid imidazole salt is hydrolyzed after reacting with methyl isocyanate in methyl chloride to obtain the target product methyl 3-isocyanothiophene -2-carboxylic acid ester.
Safety Information: The specific hazard information and toxicity of
-methyl 3-isocyanothiophene-2-carboxylate have not been systematically evaluated, so it is necessary to use caution and take appropriate protective measures during operation.
-This compound may cause irritation to the skin, eyes and respiratory tract and should be avoided.
-When using or storing, keep away from fire and high temperature.
-Must be operated in a well-ventilated place. For further information on safe operation, please consult the Safety Data Sheet (SDS) of the relevant chemical.
Nature:
-Appearance: Colorless to light yellow solid
-Melting point: 65-69°C
-Boiling point: 383°C
-Stability: stable at room temperature, but easy to get damp
-Solubility: Soluble in common organic solvents such as ethanol, acetone and dimethylformamide
Use:
-Methyl 3-isocyanothiophene-2-carboxylate is useful as an intermediate or reagent in organic synthesis.
Preparation Method:
The preparation of methyl 3-isocyanothiophene-2-carboxylate is generally carried out by the following steps:
1. First, thiophene-2-carboxylic acid ester reacts with imidazole under the action of carbonate to form thiophene-2-carboxylic acid imidazole salt.
2. Then, thiophene -2-carboxylic acid imidazole salt is hydrolyzed after reacting with methyl isocyanate in methyl chloride to obtain the target product methyl 3-isocyanothiophene -2-carboxylic acid ester.
Safety Information: The specific hazard information and toxicity of
-methyl 3-isocyanothiophene-2-carboxylate have not been systematically evaluated, so it is necessary to use caution and take appropriate protective measures during operation.
-This compound may cause irritation to the skin, eyes and respiratory tract and should be avoided.
-When using or storing, keep away from fire and high temperature.
-Must be operated in a well-ventilated place. For further information on safe operation, please consult the Safety Data Sheet (SDS) of the relevant chemical.
Last Update：2024-04-10 22:29:15
